Oscarsson J, Jansson J O, Edén S
Department of Physiology, Gothenburg University, Sweden.
Acta Physiol Scand. 1988 Jun;133(2):257-65. doi: 10.1111/j.1748-1716.1988.tb08405.x.
The effects of continuous and intermittent administration of human growth hormone (hGH) in the regulation of plasma phosphatidylcholine fatty acid composition was studied in adult hypophysectomized male and female Sprague-Dawley rats. Human GH was given for 7 days, either continuously by means of Alzet osmotic minipumps implanted s.c. or intermittently by means of s.c. injections at 12-h intervals. The 'masculinizing' effect of hypophysectomy on the fatty acid composition of plasma phosphatidylcholine in female rats, i.e. an increase in the proportions of palmitic and linoleic acids and a decrease in the proportions of stearic and arachidonic acids, was to a large extent reversed by continuous administration of hGH, while intermittent administration had no consistent effect. This effect of continuous hGH administration similar effect of continuous administration of hGH was also observed in hypophysectomized male rats. Prolactin had no effect on the fatty acid composition of phosphatidylcholine. Replacement therapy with thyroid hormones and glucocorticoids had a small effect on the proportions of palmitic and stearic acids in plasma phosphatidylcholine. It is concluded that the more continuous secretory pattern of GH in female rats is involved in the sexual differentiation of the fatty acid composition of plasma phosphatidylcholine.
在成年去垂体的雄性和雌性斯普拉格-道利大鼠中，研究了持续和间歇给予人生长激素（hGH）对血浆磷脂酰胆碱脂肪酸组成调节的影响。给予hGH 7天，通过皮下植入Alzet渗透微型泵持续给药，或通过每12小时皮下注射间歇给药。去垂体对雌性大鼠血浆磷脂酰胆碱脂肪酸组成的“雄性化”作用，即棕榈酸和亚油酸比例增加，硬脂酸和花生四烯酸比例降低，在很大程度上被持续给予hGH所逆转，而间歇给药则没有一致的效果。在去垂体的雄性大鼠中也观察到持续给予hGH的类似效果。催乳素对磷脂酰胆碱的脂肪酸组成没有影响。甲状腺激素和糖皮质激素替代疗法对血浆磷脂酰胆碱中棕榈酸和硬脂酸的比例有较小影响。结论是，雌性大鼠中更持续的GH分泌模式参与了血浆磷脂酰胆碱脂肪酸组成的性别分化。
