Schou M, Vestergaard P
Psychopharmacology Research Unit, Aarhus University Psychiatric Institute, Risskov, Denmark.
Acta Psychiatr Scand. 1988 Oct;78(4):427-33. doi: 10.1111/j.1600-0447.1988.tb06362.x.
A cohort of manic-depressive patients given prophylactic lithium treatment were examined before treatment started and at intervals during treatment for up to 7 years. The mean lithium dosage was 23.2 mmol/d and the mean serum lithium concentration 0.68 mmol/l. The treatment did not affect glomerulus function. Urine volume rose by 10-20% and renal concentrating ability fell by 7-10% during the treatment. These changes were markedly smaller than those found in patients treated previously with higher lithium doses and serum lithium concentrations. High urine volumes and low renal concentrating abilities were not more frequent during than before lithium treatment. Complaints of increased thirst, frequent urination, and nycturia were presented more often during than before lithium treatment. Serum concentrations, urinary excretions and renal clearances of sodium and potassium were not altered by the treatment.
对一组接受锂盐预防性治疗的躁郁症患者在治疗开始前及治疗期间每隔一段时间进行检查，最长达7年。平均锂剂量为23.2 mmol/d，平均血清锂浓度为0.68 mmol/l。该治疗不影响肾小球功能。治疗期间尿量增加10 - 20%，肾脏浓缩能力下降7 - 10%。这些变化明显小于先前接受较高锂剂量和血清锂浓度治疗的患者。高尿量和低肾脏浓缩能力在锂治疗期间并不比治疗前更常见。与锂治疗前相比，治疗期间更常出现口渴增加、尿频和夜尿的主诉。治疗未改变钠和钾的血清浓度、尿排泄及肾脏清除率。
