Ondo William George
Movement Disorders-Methodist Neurological Institute, Weill Cornel Medical School, 6560 Fannin Suite 1002, Houston, TX 77025, USA.
Neurol Clin. 2020 May;38(2):309-323. doi: 10.1016/j.ncl.2020.01.002. Epub 2020 Feb 29.
Established medications that improve tremor include beta-adrenergic antagonists, primidone, topiramate, and ethanol. Less consistent efficacy is reported with many other medications, usually antiepileptic drugs. A number of investigational medications, including T-type calcium channel blockers and allosteric gamma-aminobutyric acid-A modulators, are being developed for tremor. Deep brain stimulation techniques continues to be refined and focused ultrasound thalamotomy now offers an incisionless surgical option. Finally a number of peripheral electrical and mechanical devices are under development for tremor.
已证实可改善震颤的药物包括β-肾上腺素能拮抗剂、扑米酮、托吡酯和乙醇。许多其他药物（通常是抗癫痫药物）的疗效则不太一致。目前正在研发多种用于震颤治疗的试验性药物，包括T型钙通道阻滞剂和变构γ-氨基丁酸-A调节剂。深部脑刺激技术不断改进，聚焦超声丘脑切开术现在提供了一种无切口的手术选择。最后，一些用于震颤治疗的外周电气和机械设备也正在研发中。
