Vieweg W V, Godleski L S, Hundley P L, Yank G R
Western State Hospital, Department of Mental Health and Mental Retardation, Virginia.
Acta Psychiatr Scand. 1988 Oct;78(4):510-4. doi: 10.1111/j.1600-0447.1988.tb06375.x.
We evaluated diurnal weight gain and polyuria among 31 institutionalized chronically psychotic patients receiving lithium and 42 controls not receiving this drug. The patients were weighed weekly for three weeks at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and then dividing the result by the 7 a.m. weight. Polyuria was assessed using mean urine creatinine concentration (MUCR). NDWG was abnormal among study patients (1.9 +/- 1.2%) and controls (1.6 +/- 1.5%) independent of lithium treatment. The variation in MUCR explained about 20% of the variation in NDWG in both groups.
我们评估了31名接受锂盐治疗的住院慢性精神病患者和42名未接受该药物治疗的对照者的日间体重增加和多尿情况。在三周内，每周上午7点和下午4点对患者进行称重。我们通过用下午4点的体重减去上午7点的体重，将差值乘以100，然后将结果除以上午7点的体重，将日间体重增加（NDWG）标准化为百分比。使用平均尿肌酐浓度（MUCR）评估多尿情况。无论是否接受锂盐治疗，研究患者（1.9 +/- 1.2%）和对照者（1.6 +/- 1.5%）的NDWG均异常。两组中MUCR的变化解释了NDWG变化的约20%。
