共济失调治疗的现状与未来概述
An Overview of the Current State and the Future of Ataxia Treatments.
作者信息
Kwei Kimberly Tsu, Kuo Sheng-Han
机构信息
Division of Movement Disorders, Department of Neurology, Columbia University Medical Center, 610 West 168th Street, Floor 3, New York, NY 10032, USA.
Division of Movement Disorders, Department of Neurology, Columbia University Medical Center, 650 West 168th Street, Room 305, New York, NY 10032, USA.
出版信息
Neurol Clin. 2020 May;38(2):449-467. doi: 10.1016/j.ncl.2020.01.008. Epub 2020 Feb 27.
Abstract
Cerebellar ataxia can be caused by a variety of disorders, including degenerative processes, autoimmune and paraneoplastic illness as well as by gene mutations inherited in autosomal dominant, autosomal recessive, or X-linked fashions. In this review, we highlight the treatments for cerebellar ataxia in a systematic way, to provide guidance for clinicians who treat patients with cerebellar ataxia. In addition, we review therapies currently under development for ataxia, which we feel is currently one of the most exciting fields in neurology.
摘要
小脑性共济失调可由多种疾病引起，包括退行性病变、自身免疫性疾病和副肿瘤性疾病，以及常染色体显性、常染色体隐性或X连锁方式遗传的基因突变。在本综述中，我们以系统的方式重点介绍了小脑性共济失调的治疗方法，为治疗小脑性共济失调患者的临床医生提供指导。此外，我们还综述了目前正在研发的共济失调治疗方法，我们认为这是目前神经学领域最令人兴奋的领域之一。
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