Rudolf Gregory D
Swedish Pain Services, 600 Broadway Suite 530, Seattle, WA 98122, USA.
Phys Med Rehabil Clin N Am. 2020 May;31(2):195-204. doi: 10.1016/j.pmr.2020.02.001. Epub 2020 Mar 13.
The burden of chronic pain in the United States is staggering. Concurrently, the problems associated with use of opioids for treatment of chronic pain have been prominently scrutinized in recent years. Buprenorphine is an opioid that is available for treatment of both chronic pain and opioid use disorder. Its use for chronic pain has been hampered by various factors including complex and often misunderstood pharmacology, challenges to transition and induction to buprenorphine from other opioids, provider perceptions around the legality of prescribing sublingual buprenorphine for pain, and insurance coverage limitations. This article reviews the pharmacology and clinical effectiveness of buprenorphine in the context of chronic pain treatment.
美国慢性疼痛的负担惊人。与此同时，近年来，与使用阿片类药物治疗慢性疼痛相关的问题受到了广泛审视。丁丙诺啡是一种可用于治疗慢性疼痛和阿片类药物使用障碍的阿片类药物。其在慢性疼痛治疗中的应用受到多种因素的阻碍，包括复杂且常被误解的药理学、从其他阿片类药物转换和诱导使用丁丙诺啡的挑战、医疗服务提供者对舌下含服丁丙诺啡治疗疼痛合法性的认知，以及保险覆盖范围的限制。本文在慢性疼痛治疗的背景下综述了丁丙诺啡的药理学和临床疗效。
