Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 200233 Shanghai, PR China.
Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Medical College of Soochow University, 215004 Suzhou, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110841. doi: 10.1016/j.msec.2020.110841. Epub 2020 Mar 12.
The control of massive bleeding and its related wound infection is the main challenge for both military and civilian trauma centres. In this study, a cationic superabsorbent hydrogel coordinated by mesoporous silica (CSH-MS) was synthesized by free-radical polymerization for both haemostasis and antibacterial use. The as-prepared CSH-MS has a rough surface, and its water absorption is approximately 5000%. The resultant CSH-MS1 could promote blood cell aggregation and facilitate plasma protein activation via haemadsorption, resulting in efficient blood clot formation. Furthermore, CSH-MS1 (with approximately 5.06% contents of MS) dramatically reduces bleeding time and reduces blood loss in a rat-tail amputation model. Moreover, the CSH-MSs exhibits good antibacterial activities, excellent cytocompatibility and negligible haemolysis. Therefore, CSH-MS can serve as a novel type of haemostatic material in clinical applications.
控制大出血及其相关的伤口感染是军事和民用创伤中心的主要挑战。在这项研究中，通过自由基聚合合成了一种由介孔硅协调的阳离子超吸水性水凝胶（CSH-MS），用于止血和抗菌。所制备的 CSH-MS 具有粗糙的表面，其吸水率约为 5000%。所得的 CSH-MS1 可以通过血影吸附促进血细胞聚集并促进血浆蛋白激活，从而有效地形成血凝块。此外，CSH-MS1（含有约 5.06%的 MS）显著缩短了大鼠尾巴切断模型的出血时间并减少了失血量。此外，CSH-MS 还表现出良好的抗菌活性、优异的细胞相容性和可忽略不计的溶血作用。因此，CSH-MS 可用作临床应用中的新型止血材料。
