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负载龙血的介孔二氧化硅纳米颗粒用于快速止血和抗菌活性

Dragon's Blood-Loaded Mesoporous Silica Nanoparticles for Rapid Hemostasis and Antibacterial Activity.

作者信息

Yin Cuiyun, Li Yihang, Yu Jing, Deng Zhaoyou, Liu Shifang, Shi Xuanchao, Tang Deying, Chen Xi, Zhang Lixia

机构信息

Yunnan Branch, Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Jinghong 666100, China.

Key Laboratory of Sustainable Utilization of Southern Medicine, Jinghong 666100, China.

出版信息

Molecules. 2024 Apr 21;29(8):1888. doi: 10.3390/molecules29081888.

DOI:10.3390/molecules29081888
PMID:38675708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11054711/
Abstract

Dragon's blood (DB) is a traditional Chinese medicine (TCM) with hemostatic effects and antibacterial properties. However, it is still challenging to use for rapid hemostasis because of its insolubility. In this study, different amounts of DB were loaded on mesoporous silica nanoparticles (MSNs) to prepare a series of DB-MSN composites (5DB-MSN, 10DB-MSN, and 20DB-MSN). DB-MSN could quickly release DB and activate the intrinsic blood coagulation cascade simultaneously by DB and MSN. Hemostasis tests demonstrated that DB-MSN showed superior hemostatic effects than either DB or MSNs alone, and 10DB-MSN exhibited the best hemostatic effect. In addition, the antibacterial activities of DB-MSN against () and () improved with the increase in DB. Furthermore, the hemolysis assay and cytocompatibility assay demonstrated that all DB-MSNs exhibited excellent biocompatibility. Based on these results, 10DB-MSN is expected to have potential applications for emergency hemostatic and antibacterial treatment in pre-hospital trauma.

摘要

血竭是一种具有止血作用和抗菌特性的传统中药。然而，由于其不溶性，用于快速止血仍具有挑战性。在本研究中，将不同量的血竭负载于介孔二氧化硅纳米颗粒（MSN）上，制备了一系列血竭-MSN复合材料（5DB-MSN、10DB-MSN和20DB-MSN）。血竭-MSN可快速释放血竭，并通过血竭和MSN同时激活内源性凝血级联反应。止血试验表明，血竭-MSN的止血效果优于单独的血竭或MSN，其中10DB-MSN表现出最佳的止血效果。此外，血竭-MSN对（）和（）的抗菌活性随血竭含量的增加而提高。此外，溶血试验和细胞相容性试验表明，所有血竭-MSN均表现出优异的生物相容性。基于这些结果，10DB-MSN有望在院前创伤的紧急止血和抗菌治疗中具有潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/75cdcbb4df38/molecules-29-01888-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/8c6746521b4b/molecules-29-01888-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/259ed14dacda/molecules-29-01888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/3f8b1a02be17/molecules-29-01888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/df77ea88fe66/molecules-29-01888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/1d3c5864b187/molecules-29-01888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/aa6237255552/molecules-29-01888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/ba272363b0ae/molecules-29-01888-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/692b52e8dccf/molecules-29-01888-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/75cdcbb4df38/molecules-29-01888-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/8c6746521b4b/molecules-29-01888-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/259ed14dacda/molecules-29-01888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/3f8b1a02be17/molecules-29-01888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/df77ea88fe66/molecules-29-01888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/1d3c5864b187/molecules-29-01888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/aa6237255552/molecules-29-01888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/ba272363b0ae/molecules-29-01888-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/692b52e8dccf/molecules-29-01888-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3106/11054711/75cdcbb4df38/molecules-29-01888-g008.jpg

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