Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
Tuberculosis (Edinb). 2020 Mar;121:101914. doi: 10.1016/j.tube.2020.101914. Epub 2020 Feb 11.
Mycobacteria are important causes of disease in human and animal hosts. Diseases caused by mycobacteria include leprosy, tuberculosis (TB), nontuberculous mycobacteria (NTM) infections and Buruli Ulcer. To better understand and treat mycobacterial disease, clinicians, veterinarians and scientists use a range of discipline-specific approaches to conduct basic and applied research, including conducting epidemiological surveys, patient studies, wildlife sampling, animal models, genetic studies and computational simulations. To foster the exchange of knowledge and collaboration across disciplines, the Many Hosts of Mycobacteria (MHM) conference series brings together clinical, veterinary and basic scientists who are dedicated to advancing mycobacterial disease research. Started in 2007, the MHM series recently held its 8th conference at the Albert Einstein College of Medicine (Bronx, NY). Here, we review the diseases discussed at MHM8 and summarize the presentations on research advances in leprosy, NTM and Buruli Ulcer, human and animal TB, mycobacterial disease comorbidities, mycobacterial genetics and 'omics, and animal models. A mouse models workshop, which was held immediately after MHM8, is also summarized. In addition to being a resource for those who were unable to attend MHM8, we anticipate this review will provide a benchmark to gauge the progress of future research concerning mycobacteria and their many hosts.
分枝杆菌是人类和动物宿主疾病的重要病因。分枝杆菌引起的疾病包括麻风病、结核病（TB）、非结核分枝杆菌（NTM）感染和布鲁里溃疡。为了更好地了解和治疗分枝杆菌病，临床医生、兽医和科学家使用一系列特定于学科的方法进行基础和应用研究，包括进行流行病学调查、患者研究、野生动物采样、动物模型、遗传研究和计算模拟。为了促进跨学科的知识交流和合作，许多宿主的分枝杆菌（MHM）会议系列汇集了致力于推进分枝杆菌病研究的临床、兽医和基础科学家。该系列会议始于 2007 年，最近在阿尔伯特·爱因斯坦医学院（布朗克斯，NY）举行了第 8 届会议。在这里，我们回顾了 MHM8 讨论的疾病，并总结了麻风病、NTM 和布鲁里溃疡、人类和动物结核病、分枝杆菌病合并症、分枝杆菌遗传学和“组学”以及动物模型方面的研究进展。MHM8 之后还举办了一个小鼠模型研讨会，也对其进行了总结。除了为那些无法参加 MHM8 的人提供资源外，我们预计这篇综述将为衡量未来有关分枝杆菌及其众多宿主的研究进展提供一个基准。
