Departamento de Medicina Interna, Hospital General, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Arch Med Res. 2020 May;51(4):345-346. doi: 10.1016/j.arcmed.2020.03.011. Epub 2020 Apr 4.
In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that has been recognized as target to which the virus bind to cells. Although this hypothesis is possible, it may also have other explanations which are discussed.
在最近的冠状病毒病(COVID-19)疫情中,发现患有严重疾病的患者中,有更高比例的合并症患者是老年人。这种观察结果与可增加细胞表达血管紧张素转换酶 2(ACE2)的药物有关,ACE2 已被认为是病毒与细胞结合的靶标。虽然这种假设是可能的,但它也可能有其他解释,这些解释将在本文中进行讨论。