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Downregulation of ACE2 induces overstimulation of the renin-angiotensin system in COVID-19: should we block the renin-angiotensin system?

作者信息

Silhol François, Sarlon Gabrielle, Deharo Jean-Claude, Vaïsse Bernard

机构信息

Cardiology Department, HTA and Vascular Medicine University Hospital Timone, Marseille, France.

出版信息

Hypertens Res. 2020 Aug;43(8):854-856. doi: 10.1038/s41440-020-0476-3. Epub 2020 May 22.

DOI:10.1038/s41440-020-0476-3
PMID:32439915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7242178/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f28e7016487f/41440_2020_476_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f86887c0cda5/41440_2020_476_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f28e7016487f/41440_2020_476_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f86887c0cda5/41440_2020_476_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f28e7016487f/41440_2020_476_Fig2_HTML.jpg

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本文引用的文献

1
Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy.血管紧张素转换酶 2:增强血管紧张素 II 的降解,作为糖尿病肾病的潜在治疗方法。
Kidney Int. 2012 Mar;81(6):520-8. doi: 10.1038/ki.2011.381. Epub 2011 Nov 23.
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Angiotensin-converting enzyme 2 protects from severe acute lung failure.血管紧张素转换酶2可预防严重急性肺衰竭。
Nature. 2005 Jul 7;436(7047):112-6. doi: 10.1038/nature03712.
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Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
心脏和炎症生物标志物在新型冠状病毒肺炎急性呼吸窘迫综合征患者拔管失败中的预后作用
Ann Intensive Care. 2025 Jan 9;15(1):2. doi: 10.1186/s13613-025-01425-3.
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Cholesterol and Cholesterol-Lowering Medications in COVID-19-An Unresolved Matter.胆固醇和降胆固醇药物在 COVID-19 中的作用——一个悬而未决的问题。
Int J Mol Sci. 2024 Sep 29;25(19):10489. doi: 10.3390/ijms251910489.
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The "Magnificent Seven" in Oral and Systemic Health against COVID-19.口腔与全身健康对抗新冠病毒的“神奇七要素”
Endocr Metab Immune Disord Drug Targets. 2025;25(4):271-280. doi: 10.2174/0118715303296892240506100532.
6
Cholesterol and COVID-19-therapeutic opportunities at the host/virus interface during cell entry.胆固醇与 COVID-19——细胞进入过程中宿主/病毒界面的治疗机会。
Life Sci Alliance. 2024 Feb 22;7(5). doi: 10.26508/lsa.202302453. Print 2024 May.
7
Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2.SARS-CoV-2 变异株 Spike 蛋白下调 ACE2 的能力差异。
Int J Mol Sci. 2024 Jan 22;25(2):1353. doi: 10.3390/ijms25021353.
8
Persisting Shadows: Unraveling the Impact of Long COVID-19 on Respiratory, Cardiovascular, and Nervous Systems.持续的阴影:揭示新冠长期症状对呼吸、心血管和神经系统的影响
Infect Dis Rep. 2023 Dec 15;15(6):806-830. doi: 10.3390/idr15060072.
9
Combinatorial analysis of ACE and ACE2 polymorphisms reveals protection against COVID-19 worsening: A genetic association study in Brazilian patients.ACE 和 ACE2 多态性的组合分析显示其可降低 COVID-19 恶化风险:巴西患者的一项遗传关联研究。
PLoS One. 2023 Nov 30;18(11):e0288178. doi: 10.1371/journal.pone.0288178. eCollection 2023.
10
Mesenchymal Stem Cells in the Treatment of COVID-19.间充质干细胞在治疗 COVID-19 中的作用。
Int J Mol Sci. 2023 Sep 30;24(19):14800. doi: 10.3390/ijms241914800.
SARS冠状病毒功能性受体ACE2蛋白的组织分布。理解SARS发病机制的第一步。
J Pathol. 2004 Jun;203(2):631-7. doi: 10.1002/path.1570.
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Induction of cardiac fibrosis by angiotensin II.血管紧张素II诱导心脏纤维化。
Methods Find Exp Clin Pharmacol. 2000 Dec;22(10):709-23. doi: 10.1358/mf.2000.22.10.802287.
5
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.血管紧张素转换酶的一种人类同源物。作为一种对卡托普利不敏感的羧肽酶进行克隆及功能表达。
J Biol Chem. 2000 Oct 27;275(43):33238-43. doi: 10.1074/jbc.M002615200.
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Counterregulatory actions of angiotensin-(1-7).血管紧张素-(1-7)的对抗调节作用。
Hypertension. 1997 Sep;30(3 Pt 2):535-41. doi: 10.1161/01.hyp.30.3.535.