血管紧张素转换酶2（ACE2）的下调会导致新型冠状病毒肺炎（COVID-19）中肾素-血管紧张素系统的过度刺激：我们应该阻断肾素-血管紧张素系统吗？ - Suppr

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超能文献

Downregulation of ACE2 induces overstimulation of the renin-angiotensin system in COVID-19: should we block the renin-angiotensin system?

作者信息

Silhol François, Sarlon Gabrielle, Deharo Jean-Claude, Vaïsse Bernard

机构信息

Cardiology Department, HTA and Vascular Medicine University Hospital Timone, Marseille, France.

出版信息

Hypertens Res. 2020 Aug;43(8):854-856. doi: 10.1038/s41440-020-0476-3. Epub 2020 May 22.

DOI:10.1038/s41440-020-0476-3

PMID:32439915

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7242178/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/7242178/f86887c0cda5/41440_2020_476_Fig1_HTML.jpg

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本文引用的文献

Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy.血管紧张素转换酶 2：增强血管紧张素 II 的降解，作为糖尿病肾病的潜在治疗方法。

Kidney Int. 2012 Mar;81(6):520-8. doi: 10.1038/ki.2011.381. Epub 2011 Nov 23.

Angiotensin-converting enzyme 2 protects from severe acute lung failure.血管紧张素转换酶2可预防严重急性肺衰竭。

Nature. 2005 Jul 7;436(7047):112-6. doi: 10.1038/nature03712.

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.SARS冠状病毒功能性受体ACE2蛋白的组织分布。理解SARS发病机制的第一步。

J Pathol. 2004 Jun;203(2):631-7. doi: 10.1002/path.1570.

Induction of cardiac fibrosis by angiotensin II.血管紧张素II诱导心脏纤维化。

Methods Find Exp Clin Pharmacol. 2000 Dec;22(10):709-23. doi: 10.1358/mf.2000.22.10.802287.

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.血管紧张素转换酶的一种人类同源物。作为一种对卡托普利不敏感的羧肽酶进行克隆及功能表达。

J Biol Chem. 2000 Oct 27;275(43):33238-43. doi: 10.1074/jbc.M002615200.

Counterregulatory actions of angiotensin-(1-7).血管紧张素-（1-7）的对抗调节作用。

Hypertension. 1997 Sep;30(3 Pt 2):535-41. doi: 10.1161/01.hyp.30.3.535.

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