Radiation Oncology Department, Beaumont Health, Royal Oak, MI, USA.
Beaumont Biobank, Beaumont Health, Royal Oak, MI, USA.
J Alzheimers Dis. 2020;75(1):15-21. doi: 10.3233/JAD-200030.
We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.
我们之前曾报道过，低剂量的外照射电离辐射可减少淀粉样蛋白-β（Aβ）斑块并改善 APP/PS1 小鼠的认知能力。在这项研究中，我们在一组年龄匹配的 3xTg-AD 小鼠中研究了辐射的影响。用 5 次 2Gy 的半脑照射，在治疗结束后 8 周处死小鼠。使用免疫组织化学法评估 Aβ 和 tau，并使用 Definiens Tissue Studio 进行图像分析来定量。我们观察到 Aβ 斑块负担和 tau 染色显著减少；这两个参数显著相关。这些初步数据进一步支持低剂量辐射可能对阿尔茨海默病有益。
