Baniebrahimi Ghazaleh, Mir Fatemeh, Khanmohammadi Razieh
1Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Pediatric Dentistry, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Cancer Cell Int. 2020 Apr 7;20:113. doi: 10.1186/s12935-020-01192-0. eCollection 2020.
Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.
癌症干细胞（CSCs）已被确认为一小群癌细胞，它们具有与正常干细胞相同的特征。目前对癌症干细胞在转移、耐药性和癌症发生方面的作用已有足够的了解。因此，对癌症干细胞的控制可能提供一种有效的治疗干预措施来抑制肿瘤生长和侵袭。尽管靶向癌症干细胞在癌症治疗中具有重要意义，但很少有研究全面探讨口腔癌症干细胞的本质。研究表明，口腔癌症干细胞能够通过激活/抑制一系列细胞和分子途径（微小RNA网络、组蛋白修饰和钙调节）促进口腔癌进展。因此，对口腔癌的特性及其行为有更多了解将有助于我们开发新的治疗平台。头颈部癌症干细胞仍然是靶向治疗的一个可行且引人关注的选择。多项研究表明，癌症干细胞对转移、肿瘤发生以及对新治疗方案的耐药性起主要作用。因此，该领域的专家正在研究令人鼓舞的靶向治疗选择。尽管取得了进展，但该领域仍缺乏足够的信息，因此尚未找到靶向和消除癌症干细胞的神奇方法。因此，针对头颈部癌症干细胞的联合疗法的进一步研究可能会取得重大成果。本研究综述了关于口腔癌症干细胞的最新信息，并重点关注了有助于其干性调节的新信号通路的当前进展。此外，我们还强调了针对口腔癌症干细胞的各种治疗方法。
