Abbaszadeh-Goudarzi Kazem, Radbakhsh Shabnam, Pourhanifeh Mohammad Hossein, Khanbabaei Hashem, Davoodvandi Amirhosein, Fathizadeh Hadis, Sahebkar Amirhossein, Shahrzad Mohammad Karim, Mirzaei Hamed
Cellular and Molecular Research Center, Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Mol Med. 2020;20(7):516-526. doi: 10.2174/1566524020666200129142106.
Circular RNAs, a group of endogenous non-coding RNAs, are characterized by covalently closed cyclic structures with no poly-adenylated tails. It has been recently recommended that cirRNAs have an essential role in regulating genes expression by functioning as a translational regulator, RNA binding protein sponge and microRNA sponge. Due to their close relation to the progression of various diseases such as diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e., circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown to be associated with initiation and progression of diabetes. Based on reports, in a tissue, some circRNAs are expressed in a developmental stage-specific manner. In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.
环状RNA是一类内源性非编码RNA，其特征是具有共价闭合的环状结构，没有多聚腺苷酸尾巴。最近有人提出，环状RNA通过作为翻译调节因子、RNA结合蛋白海绵和微小RNA海绵发挥作用，在调节基因表达中起重要作用。由于环状RNA与糖尿病等各种疾病的进展密切相关，它们已成为一个研究热点。一些环状RNA（即circRNA_0054633、circHIPK3、circANKRD36和circRNA11783-2）已被证明与糖尿病的发生和发展有关。根据报道，在一种组织中，一些环状RNA以发育阶段特异性的方式表达。在本研究中，我们综述了环状RNA在糖尿病发病机制、诊断及其预后作用方面的研究。
