Grzelewska-Rzymowska I
Department of Pneumonology and Allergology, Medical Academy of Lodz, Poland.
Allergol Immunopathol (Madr). 1988 Jul-Aug;16(4):231-6.
In order to establish the role of mast cells in aspirin-induced urticaria and angioedema, neutrophil chemotactic activity (NCA) in serum was assayed using the method of Nelson before and after aspirin challenge. In 14 (82.4%) persons sensitive to aspirin an increase in NCA during aspirin-induced urticaria and angioedema was observed and in 9 of them (52.9%) it was considerable (index NCA greater than or equal to 2.0). None of the 18 persons from the control group with idiopathic urticaria and/or angioedema but without aspirin-sensitivity exhibit an increase in NCA after aspirin challenge. The author assumes that mast cell degranulation does occur in aspirin-induced urticaria and angioedema.
为了确定肥大细胞在阿司匹林诱发的荨麻疹和血管性水肿中的作用，采用纳尔逊方法在阿司匹林激发前后检测血清中的中性粒细胞趋化活性（NCA）。在14名（82.4%）对阿司匹林敏感的患者中，观察到在阿司匹林诱发的荨麻疹和血管性水肿期间NCA增加，其中9名（52.9%）增加显著（NCA指数大于或等于2.0）。对照组中18名患有特发性荨麻疹和/或血管性水肿但无阿司匹林敏感性的患者，在阿司匹林激发后均未出现NCA增加。作者认为在阿司匹林诱发的荨麻疹和血管性水肿中确实发生了肥大细胞脱颗粒。
