Grzelewska-Rzymowska I, Szmidt M, Grzegorczyk J, Rozniecki J
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
Pneumonol Alergol Pol. 1993;61(7-8):357-61.
The increase in neutrophil chemotactic activity (NCA) is related to degranulation of mast cells. The study included 10 patients in whom aspirin-induced urticaria was related to NCA increase. Tolerance state to ASA was achieved by administering this drug in incremental doses. In none of the examined patients after 600 mg of ASA given during induced tolerance state, the increase of NCA was observed. The authors conclude that in patients with ASA-urticaria, after ASA desensitization, mast cells degranulation does not occur.
中性粒细胞趋化活性（NCA）的增加与肥大细胞脱颗粒有关。该研究纳入了10例阿司匹林诱导的荨麻疹与NCA增加相关的患者。通过递增剂量给药使患者达到对阿司匹林的耐受状态。在诱导耐受状态下给予600mg阿司匹林后，在所检查的患者中均未观察到NCA增加。作者得出结论，在阿司匹林性荨麻疹患者中，阿司匹林脱敏后肥大细胞不会发生脱颗粒。
