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Evaluating the uncertainty of risk prediction in genetic counseling: a Bayesian approach.

作者信息

Rogatko A

机构信息

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

出版信息

Am J Med Genet. 1988 Nov;31(3):513-9. doi: 10.1002/ajmg.1320310305.

DOI:10.1002/ajmg.1320310305
PMID:3228134
Abstract

A general method to obtain the exact point estimate and the measure of uncertainty of recurrence risks for genetic counseling is present. This method, which follows Bayesian estimation theory, can be applied without restrictions of sample size, class of risk function, or parameter dimension. As an illustration, the recurrence risks for isolated cases in two autosomal dominant disorders with incomplete penetrance (mandibulofacial and fontonasal dyostoses) are estimated.

摘要

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