Wilkin T J, Storey B E, Isles T E, Crooks J, Beck J S
Br Med J. 1977 Apr 16;1(6067):993-6. doi: 10.1136/bmj.1.6067.993.
High concentrations of thyroid-stimulating hormone (TSH) in the serum have often been reported in apparently euthyroid patients with damaged thyroids. We have confirmed this finding in 14 patients 18 months after subtotal thyroidectomy for Graves's disease (group 1) and in 14 patients with manic-depressive psychosis (group 2) receiving lithium carbonate, which reduces thyroid reserve. One factor common to groups 1 and 2 but not to the controls was reduced thyroid reserve or functioning capacity, and, using established physical principles of servo-control, we have tried to define the mechanism. A series of curves were projected to indicate how TSH might be expected to vary with functioning thyroid capacity.
血清中促甲状腺激素（TSH）浓度高的情况，在甲状腺受损但甲状腺功能看似正常的患者中常有报道。我们在因格雷夫斯病行甲状腺次全切除术后18个月的14例患者（第1组）以及在接受碳酸锂治疗（碳酸锂会降低甲状腺储备）的14例躁狂抑郁症患者（第2组）中证实了这一发现。第1组和第2组共有的、而对照组没有的一个因素是甲状腺储备或功能能力降低，并且我们利用既定的伺服控制物理原理，试图确定其机制。绘制了一系列曲线，以表明促甲状腺激素可能会如何随甲状腺功能能力而变化。
