Hennemann G, Van Welsum M, Bernard B, Docter R, Visser T J
Br Med J. 1975 Oct 18;4(5989):129-30. doi: 10.1136/bmj.4.5989.129.
Three groups of patients who had undergone subtotal thyroidectomy for Graves's disease, toxic multinodular goitre, or euthyroid multinodular goitre 12 to 15 years before and in whom a normal serum thyroxine (T-4) level was found were each divided into two subgroups on the basis of a normal or a raised serum thyrotrophin concentration. There was no difference in mean serum T-4 concentration between patients with normal and those with raised serum thyrotrophin concentrations, and the values were similar to the mean T-4 values of the normal population. The mean serum triiodothyronine values of all groups were higher than normal, but the mean values of the groups with a normal and a raised serum thyrotrophin were similar. After thyroidectomy a mildly raised serum thyrotrophin does not in itself indicate the presence of hypothyroidism.
三组患者在12至15年前因格雷夫斯病、毒性多结节性甲状腺肿或甲状腺功能正常的多结节性甲状腺肿接受了甲状腺次全切除术，且血清甲状腺素（T-4）水平正常，根据血清促甲状腺素浓度正常或升高，每组又分为两个亚组。血清促甲状腺素浓度正常的患者与升高的患者之间，平均血清T-4浓度无差异，这些值与正常人群的平均T-4值相似。所有组的平均血清三碘甲状腺原氨酸值均高于正常，但血清促甲状腺素正常和升高组的平均值相似。甲状腺切除术后，血清促甲状腺素轻度升高本身并不表明存在甲状腺功能减退。
