在弥漫性大 B 细胞淋巴瘤中鉴定乙型肝炎病毒病因抗原 HBx 和 Pre-S2。
Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma.
机构信息
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Department of Pediatric Gastroenterology, The First Hospital of Jilin University, Changchun, China.
出版信息
J Viral Hepat. 2020 Sep;27(9):948-950. doi: 10.1111/jvh.13301. Epub 2020 Apr 28.
Diffuse large B-cell lymphoma (DLBCL) has been reported to have a significant association with the hepatitis B virus (HBV) infection. However, there has been no experimental evidence to determine whether the components of the hepatitis B virus are expressed in lymphoid cells. In this study, we used immunohistochemical methods to explore whether the antigens of hepatitis B virus are expressed in DLBCL lymphoma cells in HBsAg-positive DLBCL patients (HBsAg + DLBCL). HBx antigen was detected in 48.9% of HBsAg + DLBCL patients, and the expression rate of the Pre-S2 antigen was 57.2%. HBx expression was significantly associated with high-level expression of c-Myc, while the Pre-S2 antigen was not. In this study, we demonstrated that HBx antigen and Pre-S2 antigen could be detected in lymphoma cells, and HBx expression was related to c-Myc expression. Our findings provide a strong basis for further study of the HBV-infected DLBCL and molecular mechanism underlying the lymphomagenesis.
弥漫性大 B 细胞淋巴瘤（DLBCL）与乙型肝炎病毒（HBV）感染有显著相关性。然而，目前尚无实验证据表明乙型肝炎病毒的成分是否在淋巴细胞中表达。在这项研究中，我们使用免疫组织化学方法来探讨 HBsAg 阳性 DLBCL 患者（HBsAg+DLBCL）的 DLBCL 淋巴瘤细胞中是否表达乙型肝炎病毒的抗原。在 48.9%的 HBsAg+DLBCL 患者中检测到 HBx 抗原，Pre-S2 抗原的表达率为 57.2%。HBx 表达与 c-Myc 的高水平表达显著相关，而 Pre-S2 抗原则没有。在这项研究中，我们证明了 HBx 抗原和 Pre-S2 抗原可以在淋巴瘤细胞中检测到，并且 HBx 表达与 c-Myc 表达有关。我们的研究结果为进一步研究 HBV 感染的 DLBCL 和淋巴瘤发生的分子机制提供了有力依据。
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