Piérard-Franchimont C, Piérard G E
Dermatopathology Service, University of Liège, Belgium.
Am J Dermatopathol. 1988 Oct;10(5):419-23.
Cantharidin has been used to induce acantholysis in vivo. Intraepidermal clefting starts at the junction between the basal and epidermal layers, and later involves all of the levels of the stratum spinosum. As a response to early acantholysis, an increased number of epibasal cells synthesize DNA. This is not related to an increased binding of epidermal growth factor to these cells. In sum, the basal-epibasal junction is one of the weakest within the epidermis. The epibasal cells represent a reserve pool for proliferating keratinocytes that may be stimulated without necessarily binding an increased amount of epidermal growth factor.
斑蝥素已被用于在体内诱导棘层松解。表皮内裂隙形成始于基底层和表皮层之间的交界处，随后累及棘层的所有层次。作为对早期棘层松解的一种反应，基底上细胞合成DNA的数量增加。这与表皮生长因子与这些细胞的结合增加无关。总之，基底-基底上交界处是表皮内最薄弱的部位之一。基底上细胞代表了增殖角质形成细胞的储备池，这些细胞可能在不一定结合增加量的表皮生长因子的情况下受到刺激。
