Kuhn A, Groth W, Gartmann H, Steigleder G K
Department of Dermatology, University of Cologne, Köln, F.R.G.
Am J Dermatopathol. 1988 Oct;10(5):436-41.
A malignant blue nevus of the right upper arm with hematogeneous lung metastases is presented. Histological examination showed that the tumor was composed of spindle, dendritic, and globular cells with hyperchromatic and polymorphic nuclei, atypical mitoses, and tumor cell necrosis. There was no proliferation of atypical melanocytes at the dermoepidermal junction. Histologically, malignant blue nevus should be distinguished from benign cellular blue nevus, primary cutaneous malignant melanoma, cutaneous metastases of malignant melanoma, and clear cell sarcoma.
本文报告一例右上臂恶性蓝色痣伴血行性肺转移。组织学检查显示，肿瘤由梭形、树枝状和球状细胞组成，细胞核深染且形态多样，可见非典型有丝分裂及肿瘤细胞坏死。真皮表皮交界处未见非典型黑素细胞增殖。组织学上，恶性蓝色痣应与良性细胞性蓝色痣、原发性皮肤恶性黑色素瘤、恶性黑色素瘤皮肤转移及透明细胞肉瘤相鉴别。
