Otolaryngology Department, Naval Medical Center San Diego, 34800 Bob Wilson Dr, Suite 5, San Diego, CA 92134, USA.
J Am Acad Dermatol. 2010 May;62(5):869-74. doi: 10.1016/j.jaad.2009.09.003. Epub 2010 Jan 13.
The mongolian spot, nevus of Ota, and nevus of Ito are the most common morphologic forms of the dermal melanocytoses, a group of benign pigmented lesions histologically characterized by the presence of melanocytes within the dermis. Nevus of Ito is clinically distinct, presenting with unilateral, bluish gray, patchy discolorations in the skin within the distributions of the posterior supraclavicular and lateral cutaneous brachial nerves. Although all dermal melanocytoses are generally considered benign, rare cases of malignant transformation associated with nevus of Ota have been described. Only one case of malignant melanoma transformation in association with nevus of Ito has previously been reported. We present the second description of malignant melanoma transformation within a nevus of Ito and provide comment on the malignant potential of the dermal melanocytoses.
蒙古斑、伊藤痣和伊藤母斑是真皮黑素细胞增多症最常见的形态学类型，一组组织学上以真皮内存在黑素细胞为特征的良性色素性病变。伊藤母斑具有独特的临床表现，表现为单侧、蓝灰色、斑片状的皮肤变色，分布于锁骨后上和外侧臂皮神经。虽然所有真皮黑素细胞增多症通常被认为是良性的，但已描述了与伊藤痣相关的罕见恶变病例。以前曾有一例与伊藤母斑相关的恶性黑色素瘤转化的报道。我们报告了第二例伊藤母斑内恶性黑色素瘤转化，并对真皮黑素细胞增多症的恶变潜能进行了讨论。
