阿莫西林治疗淋病的双盲试验。
A double trial of amoxycillin in the treatment of gonorrhoea.
作者信息
Thin R N, Symonds M A, Shaw E J, Wong J, Hopper P K, Slocombe B
出版信息
Br J Vener Dis. 1977 Apr;53(2):118-20. doi: 10.1136/sti.53.2.118.
A double blind comparison of two regimens of amoxycillin plus probenecid in the treatment of uncomplicated anogenital gonorrhoea is reported. Forty-three (86-0%) of 50 patients treated with 1 g amoxycillin plus 1 g probenecid and followed-up for 14 days were regarded as cured, and 51 (94-4%) of 54 patients treated with 3 g amoxycillin plus 1 g probenecid were regarded as cured. Fifty-nine per cent of 69 isolates of Neisseria gonorrhoeae were sensitive to amoxycillin (minimum inhibitory concentration less than or equal to 0-05 mg/ml). Although there was no statistical difference between the results of the two regimens it is concluded that the larger dose of amoxycillin plus probenecid is required where only 60% of gonococci are sensitive to amoxycillin.
本文报道了两种阿莫西林加丙磺舒治疗单纯性肛门生殖器淋病方案的双盲比较。50例接受1g阿莫西林加1g丙磺舒治疗并随访14天的患者中，43例（86.0%）被视为治愈；54例接受3g阿莫西林加1g丙磺舒治疗的患者中，51例（94.4%）被视为治愈。69株淋病奈瑟菌分离株中，59%对阿莫西林敏感（最低抑菌浓度小于或等于0.05mg/ml）。虽然两种方案的结果无统计学差异，但得出结论：在仅60%的淋球菌对阿莫西林敏感的情况下，需要使用更大剂量的阿莫西林加丙磺舒。
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