阿莫西林、氨苄西林加丙磺舒治疗男性淋病的双盲试验。
Double-blind trial of amoxycillin and ampicillin plus probenecid in the treatment of gonorrhoea in men.
作者信息
Brathwaite A R
出版信息
Br J Vener Dis. 1979 Oct;55(5):340-2. doi: 10.1136/sti.55.5.340.
Abstract
In a double-blind study amoxycillin 3 g or ampicillin 3 g plus probenecid 1 g were randomly administered as a single oral dose to 160 men with uncomplicated gonococcal urethritis. The cure rate for each drug group was 98.6%. Tolerance to oral medication was good and no evidence of allergy or toxicity to either drug was shown. No case of post-gonococcal urethritis was observed over a 14-day follow-up period. Thus, both drug regimens proved very effective in treating uncomplicated gonococcal urethritis in men.
摘要
在一项双盲研究中，将3克阿莫西林或3克氨苄西林加1克丙磺舒随机作为单次口服剂量给予160例患有单纯性淋菌性尿道炎的男性。每个药物组的治愈率均为98.6%。口服药物耐受性良好，未显示对任何一种药物有过敏或毒性迹象。在14天的随访期内未观察到淋菌性尿道炎后尿道炎病例。因此，两种药物治疗方案在治疗男性单纯性淋菌性尿道炎方面均证明非常有效。
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本文引用的文献
1
-amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: absorption and excretion in man.
Antimicrob Agents Chemother (Bethesda). 1970;10:427-30.
2
Single oral dose ampicillin-probenecid treatment of gnorrhea in the male.
JAMA. 1971 Mar 1;215(9):1449-53.
3
-amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: in vitro evaluation.
Antimicrob Agents Chemother (Bethesda). 1970;10:411-5. doi: 10.1128/AAC.10.3.411.
4
Treatment of gonorrhoea with amoxycillin.
Br J Vener Dis. 1973 Jun;49(3):274-6. doi: 10.1136/sti.49.3.274.
5
Amoxycillin: a new semi-synthetic penicillin.
Br Med J. 1972 Jul 1;3(5817):13-6. doi: 10.1136/bmj.3.5817.13.
6
Penicillin and tetracycline sensitivity of Jamaican strains of gonococci.
West Indian Med J. 1974 Dec;23(4):226-31.
7
Effective treatment of gonorrhoea in London with two oral doses of amoxycillin.
Br J Vener Dis. 1974 Apr;50(2):120-4. doi: 10.1136/sti.50.2.120.
8
Amoxycillin in the treatment of gonorrhoea.
Br J Vener Dis. 1975 Dec;51(6):398-400. doi: 10.1136/sti.51.6.398.
9
A double trial of amoxycillin in the treatment of gonorrhoea.
Br J Vener Dis. 1977 Apr;53(2):118-20. doi: 10.1136/sti.53.2.118.
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