Key P R, Azadian B S, Evans B A
Genitourin Med. 1985 Jun;61(3):165-7. doi: 10.1136/sti.61.3.165.
We studied 220 patients (138 men and 82 women) with uncomplicated gonorrhoea who were entered into a randomised double blind trial and treated with either Augmentin (amoxycillin 3 g and potassium clavulanate 125 mg) or amoxycillin 3 g, with probenecid 1 g by mouth in all cases. Seven (6.5%) of 108 patients treated with Augmentin were still culture positive after treatment, compared with 15 (13.4%) of 112 of those treated with amoxycillin. Penicillinase (beta lactamase) producing strains of Neisseria gonorrhoeae (PPNG) were found in 23 (10.5%) patients, of whom 10 were treated with Augmentin and 13 with amoxycillin. Treatment failed in all 13 patients who received amoxycillin. Augmentin was shown to be an effective treatment for gonorrhoea caused by PPNG strains.
我们研究了220例无并发症淋病患者（138名男性和82名女性），这些患者进入了一项随机双盲试验，分别接受奥格门汀（阿莫西林3g和克拉维酸钾125mg）或阿莫西林3g治疗，所有病例均口服丙磺舒1g。接受奥格门汀治疗的108例患者中，7例（6.5%）治疗后培养仍为阳性，而接受阿莫西林治疗的112例患者中有15例（13.4%）培养仍为阳性。在23例（10.5%）患者中发现了产青霉素酶（β-内酰胺酶）的淋病奈瑟菌（PPNG）菌株，其中10例接受奥格门汀治疗，13例接受阿莫西林治疗。接受阿莫西林治疗的13例患者治疗均失败。奥格门汀被证明是治疗PPNG菌株引起的淋病的有效药物。
