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Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis.

作者信息

Kojima Yoko, Ye Jianqin, Nanda Vivek, Wang Ying, Flores Alyssa M, Jarr Kai-Uwe, Tsantilas Pavlos, Guo Liang, Finn Aloke V, Virmani Renu, Leeper Nicholas J

机构信息

Department of Surgery, Division of Vascular Surgery (Y.K., J.Y., V.N., Y.W., A.M.F., K.-U.J., P.T., N.J.L.), Stanford University School of Medicine, CA.

CVPath Institute, Gaithersburg, MD (L.G., A.V.F., R.V.).

出版信息

Circulation. 2020 Apr 14;141(15):1274-1276. doi: 10.1161/CIRCULATIONAHA.119.043413. Epub 2020 Apr 13.

DOI:10.1161/CIRCULATIONAHA.119.043413
PMID:32282248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7158761/
Abstract
摘要

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本文引用的文献

1
Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?9p21.3 位点致动脉粥样硬化的功能基因组学：清晰还是混乱？
Curr Cardiol Rep. 2014 Jul;16(7):502. doi: 10.1007/s11886-014-0502-7.
2
Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques.动脉粥样硬化性冠心病的组织病理学特征及其对易损斑块侵袭性和非侵袭性检测的意义。
J Am Coll Cardiol. 2013 Mar 12;61(10):1041-51. doi: 10.1016/j.jacc.2012.10.054.
3
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.9p21 染色体位点与冠状动脉疾病负担的相关性：一项合作荟萃分析。
J Am Coll Cardiol. 2013 Mar 5;61(9):957-70. doi: 10.1016/j.jacc.2012.10.051. Epub 2013 Jan 23.
4
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.全基因组关联研究冠状动脉钙化并随访心肌梗死。
Circulation. 2011 Dec 20;124(25):2855-64. doi: 10.1161/CIRCULATIONAHA.110.974899. Epub 2011 Dec 5.
5
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice.在小鼠中靶向敲除 9p21 非编码冠心病风险区间。
Nature. 2010 Mar 18;464(7287):409-12. doi: 10.1038/nature08801. Epub 2010 Feb 21.