O'Kusky J, Strauss E, Kosaka B, Wada J, Li D, Druhan M, Petrie J
Department of Pathology, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1988 Sep;24(3):379-83. doi: 10.1002/ana.410240305.
Variations in the size of the human corpus callosum were examined as a possible morphological substrate of functional asymmetries of the cerebral hemispheres, such as cerebral speech dominance. The midsagittal surface area of the corpus callosum, obtained by magnetic resonance imaging, was measured in 50 patients with epilepsy and 50 neurologically normal control subjects. The mean callosal area did not differ significantly between patients and control subjects, between left-handed and right-handed subjects, or between men and women. When measurements were compared among 44 patients, whose cerebral speech dominance had been determined by the intracarotid injection of sodium amytal, the area of the corpus callosum was significantly greater in patients with right-hemisphere cerebral speech dominance. The mean callosal area was greater by 109 to 159 square millimeters (18-28%) when compared to that of patients with either left-hemisphere speech dominance or bilateral speech representation. This difference in midsagittal surface area could represent as many as 37 to 54 million additional callosal axons in subjects with right-hemisphere cerebral speech dominance.
对人类胼胝体大小的差异进行了研究，将其作为大脑半球功能不对称（如大脑语言优势）可能的形态学基础。通过磁共振成像获得胼胝体的矢状中面面积，对50例癫痫患者和50例神经功能正常的对照者进行了测量。患者与对照者之间、左利手与右利手者之间、男性与女性之间的胼胝体平均面积无显著差异。在44例经颈动脉注射异戊巴比妥钠确定大脑语言优势的患者中进行比较时，右半球大脑语言优势患者的胼胝体面积显著更大。与左半球语言优势或双侧语言表征的患者相比，胼胝体平均面积大109至159平方毫米（18 - 28%）。矢状中面面积的这种差异可能意味着右半球大脑语言优势的受试者额外有多达3700万至5400万个胼胝体轴突。
