Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam.
Department of Applied Chemistry and Chemical Engineering, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
J Ethnopharmacol. 2020 Jul 15;257:112853. doi: 10.1016/j.jep.2020.112853. Epub 2020 Apr 10.
Piper chaba Hunter, called Chui Jhal or Choi Jhal, is commonly used as a culinary (spice) herb in India and Bangladesh. It exhibits numerous important biological activities and has been widely used in traditional medicine.
This review focuses on the chemical and pharmacological activities of a culinary ingredient P. chaba based on information extracted from the literature to highlight its use in traditional medicine.
A literature search in known databases was conducted (till September 2019) for published articles using the relevant keywords.
Findings suggest that, to date, a number of important phytoconstituents such as dimeric alkaloids, and alkamides have been isolated from various parts of P. chaba. Extracts from P. chaba or derived compounds exhibit diverse biological activities, such as anti-microbial, anti-leishmanial, anti-malarial, anti-parasitic, cytotoxic/anticancer, adipogenic, hepato- and gastro-protective, anti-diabetic, analgesic, anti-diarrheal, depressive, anti-inflammatory, diuretic, anti-hypertensive, antipyretic, anti-ulcer, and immunomodulatory effect. Among the isolated compounds, chabamides, piperine, piplartine, retrofractamides A/B, methylenedioxyphenyl)-nona-2E,4E,8E-trienoic acid, n-butyl or n-pentyl amine, piperlonguminine, pipernonaline, dehydropipernonaline, N-isobutyl-(2E,4E)-octadecadienamide, and N-isobutyl-(2E,4E,14Z)-eicosatrienamide have documented important biological effects in various test systems.
Taken together, P. chaba may be a potential source of plant-based therapeutic lead compounds, which justify its uses in traditional medicine.
Piper chaba Hunter，被称为 Chui Jhal 或 Choi Jhal，在印度和孟加拉国通常被用作烹饪（香料）草药。它表现出许多重要的生物活性，并已被广泛用于传统医学。
本综述重点介绍了烹饪成分 Piper chaba 的化学成分和药理活性，这些信息是从文献中提取出来的，以突出其在传统医学中的用途。
在已知数据库中进行了文献检索（截至 2019 年 9 月），使用相关关键词检索已发表的文章。
研究结果表明，迄今为止，已经从 Piper chaba 的各个部位分离出了一些重要的植物化学成分，如二聚生物碱和烷酰胺。Piper chaba 的提取物或衍生化合物表现出多种生物活性，如抗微生物、抗利什曼原虫、抗疟疾、抗寄生虫、细胞毒性/抗癌、脂肪生成、肝和胃保护、抗糖尿病、镇痛、抗腹泻、抑郁、抗炎、利尿、抗高血压、退热、抗溃疡和免疫调节作用。在分离出的化合物中，chabamides、胡椒碱、piplartine、retrofractamides A/B、(methylenedioxyphenyl)-nona-2E,4E,8E-trienoic acid、n-butyl 或 n-pentyl amine、piperlonguminine、pipernonaline、dehydropipernonaline、N-isobutyl-(2E,4E)-octadecadienamide 和 N-isobutyl-(2E,4E,14Z)-eicosatrienamide 在各种测试系统中具有重要的生物效应。
综上所述，Piper chaba 可能是植物治疗性先导化合物的潜在来源，这证明了其在传统医学中的应用。
