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经治疗的硬化性腹膜炎伴黄素化间质瘤完全缓解。

COMPLETE REMISSION OF MEDICALLY TREATED LUTEINIZED THECOMAS WITH SCLEROSING PERITONITIS.

机构信息

Department of Obstetrics and Gynecology, Maison Blanche Hospital, Reims Champagne-Ardenne university, 45, Cognacq-Jay, 51100, Reims, France.

Department of general, digestive and endocrine surgery, Robert-Debré hospital, Reims Champagne-Ardenne university, 8, rue du général Koenig, 51100, Reims, France.

出版信息

J Gynecol Obstet Hum Reprod. 2021 Jun;50(6):101734. doi: 10.1016/j.jogoh.2020.101734. Epub 2020 Apr 10.

Abstract

We describe the first French patient treated for sclerosing peritonitis syndrome associated with lutheinized thecomas. At 42 years old, she had respiratory distress with increased abdominal volume. Physical examination revealed ascites, pleural effusions, and two mobile latero-uterine masses. Radiological examinations revealed bilateral ovarian masses of 10 cm. Bilateral adnexectomy was performed by laparotomy. Histological analysis concluded that there were benign luteinized thecomas. Until the 36th postoperative day, the general condition of the patient deteriorated to become critical. A second surgical procedure was attempted revealing sclerosing fibrosis preventing access to the peritoneal cavity. Subsequently, a medical treatment combining parenteral nutrition, high intravenous doses of corticosteroids, antiestrogens, colchicine and sandostatin was administered and effective allowing continuity recovery 15 months later. The clinical outcomes has been favorable at 24 month later.

摘要

我们描述了首例法国患者,其患有与黄体化间质瘤相关的硬化性腹膜炎综合征。该患者 42 岁,出现呼吸困难伴腹部体积增大。体格检查发现腹水、胸腔积液和两个可移动的侧-子宫肿块。影像学检查显示双侧卵巢肿块为 10cm。通过剖腹手术进行双侧附件切除术。组织学分析得出结论为良性黄体化间质瘤。直到术后第 36 天,患者的一般状况恶化,变得危急。尝试进行了第二次手术,但发现硬化性纤维化阻碍了进入腹腔。随后,给予了一种结合肠外营养、大剂量静脉内皮质类固醇、抗雌激素、秋水仙碱和生长抑素的药物治疗,并取得了疗效,15 个月后患者得以继续康复。24 个月后,临床结果良好。

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