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[阿他司利德对腹膜巨噬细胞刺激作用的影响]

[Effect of astasilid on the stimulation of peritoneal macrophages].

作者信息

Makarenko I G, Sukhareva N N, Khorokhorina V A

出版信息

Antibiot Khimioter. 1988 Nov;33(11):833-5.

PMID:3228323
Abstract

The effect of astasilid, a sucrose monoester and the effect of mainly unsaturated fatty acids from the lipid fraction of Astasia longa on immunocompetent cells--macrophages of the mouse peritoneal cavity were studied. It was shown that astasilid increased 7.5-8.5-fold expression of Fc-receptors on the macrophage plasmic membranes and stimulated 5.5-6.5-fold the macrophage capacity for Fc-dependent phagocytosis of sheep red blood cells. Astasilid had no effect on migration of the macrophages into the abdominal cavity.

摘要

研究了长眼虫属中的蔗糖单酯astasilid以及长眼虫属脂质部分中主要不饱和脂肪酸对免疫活性细胞——小鼠腹腔巨噬细胞的影响。结果表明,astasilid使巨噬细胞质膜上Fc受体的表达增加了7.5至8.5倍,并使巨噬细胞对绵羊红细胞的Fc依赖性吞噬能力提高了5.5至6.5倍。Astasilid对巨噬细胞向腹腔的迁移没有影响。

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