İstanbul Physical Medicine and Rehabilitation Training and Research Hospital, İstanbul, Turkey
Bakırköy Dr. Sadi Konuk Training Hospital, İstanbul, Turkey
Turk J Med Sci. 2020 Jun 23;50(4):994-998. doi: 10.3906/sag-1909-187.
BACKGROUND/AIM: β1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of β1-selective BBs on bone mineral density (BMD) and fracture risk.
This study included postmenopausal women who used β1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX).
A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group (P = 0.015 and P = 0.025, respectively). Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX.
Based on our results, β1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.
背景/目的：β1 选择性β受体阻滞剂（BB）是一种拟交感神经药物，了解它们对骨骼健康的影响非常重要。本研究旨在探讨β1 选择性 BB 对骨密度（BMD）和骨折风险的影响。
本研究纳入了使用β1 选择性 BB 的绝经后女性（BB 组）和对照组。记录了社会人口统计学特征、BMD 和既往脆性骨折情况。此外，使用骨折风险评估工具（FRAX）计算了 10 年内发生主要骨质疏松性骨折和髋部骨折的概率。
本研究共纳入 60 名参与者。与对照组相比，BB 组的 L1-4 和 L2-4 BMD 值显著更高（P = 0.015 和 P = 0.025）。此外，BB 组的腰椎和股骨总 T 评分也显著更高。BB 组有 2 名患者和对照组有 6 名患者有既往脆性骨折。FRAX 两组间无统计学显著差异。
根据我们的结果，β1 选择性 BB 使用与绝经后女性腰椎区域更高的 BMD 相关。
