Laboratory of Metabolism and Drug Target Discovery, State Key Laboratory of Natural Medicines, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Laboratory of Metabolism and Drug Target Discovery, State Key Laboratory of Natural Medicines, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Trends Endocrinol Metab. 2020 Nov;31(11):818-834. doi: 10.1016/j.tem.2020.02.012. Epub 2020 Apr 10.
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may regulate immune, metabolic, and neuronal responses at local and distant sites. Such a chemical dialog between host cells and the gut microbiome is shaped by environmental cues, and may become dysregulated in gastrointestinal and systems diseases. Increasing knowledge of the bacterial pathway and signaling basis may shed additional light on metabolic host-microbiome crosstalk that remains untapped for drug discovery. Here, we update our understanding of microbial AAA metabolism and its impacts on host physiology and disease. We also consider open questions related to therapeutically mining these signaling metabolites and how recent concepts and tools may drive this area forward.
肠道微生物代谢与宿主健康和疾病密切相关。肠道微生物群分解芳香族氨基酸（AAA）会产生许多代谢物，这些代谢物可能会调节局部和远处的免疫、代谢和神经元反应。这种宿主细胞与肠道微生物群之间的化学对话受到环境线索的影响，并且可能在胃肠道和系统疾病中失调。增加对细菌途径和信号基础的了解，可能会进一步揭示代谢性宿主-微生物群相互作用的信息，而这些信息尚未被用于药物发现。在这里，我们更新了对微生物 AAA 代谢及其对宿主生理学和疾病影响的认识。我们还考虑了与从这些信号代谢物中进行治疗性挖掘相关的开放性问题，以及最近的概念和工具如何推动这一领域的发展。
