Kobayashi Atsushi
Laboratory of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University.
Brain Nerve. 2020 Apr;72(4):437-443. doi: 10.11477/mf.1416201542.
Recent progress in understanding of iatrogenic Creutzfeldt-Jakob disease (CJD) has revealed pathological and biochemical features specific to patients with iatrogenic CJD Based on the pathological and biochemical characteristics, we have identified iatrogenic CJD cases among presumed sporadic cases; in a neurosurgeon and in a patient with a medical history of neurosurgery. In addition, incidents of suspected CJD exposure via contaminated neurosurgical instruments are occasionally noted. Therefore, improvement of CJD case recognition and tracking of neurosurgical instruments are necessary to prevent iatrogenic CJD transmission via neurosurgical instruments. Further, accumulating evidence suggests that certain misfolded proteins and amyloid proteins, as well as prion proteins, are transmissible between individuals. Evaluation of the potential risks of iatrogenic transmission and the development of preventative strategies for these infectious proteins are our future tasks.
对医源性克雅氏病（CJD）认识的最新进展揭示了医源性CJD患者特有的病理和生化特征。基于这些病理和生化特征，我们在疑似散发性病例中识别出了医源性CJD病例；一例是神经外科医生，另一例有神经外科手术病史。此外，偶尔会注意到通过受污染的神经外科器械接触疑似CJD的事件。因此，提高CJD病例识别能力并追踪神经外科器械对于预防通过神经外科器械传播医源性CJD是必要的。此外，越来越多的证据表明，某些错误折叠的蛋白质、淀粉样蛋白以及朊病毒蛋白可在个体之间传播。评估医源性传播的潜在风险并制定针对这些传染性蛋白质的预防策略是我们未来的任务。
