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急性胰腺炎风险与选择性5-羟色胺再摄取抑制剂的使用：病例对照研究的荟萃分析

The Risk of Acute Pancreatitis and Selective Serotonin Reuptake Inhibitors Use: A Meta-Analysis of Case-Control Studies.

作者信息

Lai Shih-Wei, Yu Cheng-Chan, Lin Cheng-Li, Liao Kuan-Fu

机构信息

College of Medicine, China Medical University, Taichung.

Department of Family Medicine, China Medical University Hospital, Taichung.

出版信息

Dose Response. 2020 Mar 30;18(1):1559325820902352. doi: 10.1177/1559325820902352. eCollection 2020 Jan-Mar.

DOI:10.1177/1559325820902352
PMID:32284693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7133076/
Abstract

BACKGROUND/OBJECTIVE: Some case series and case report have shown the association between the risk of acute pancreatitis and use of selective serotonin reuptake inhibitors. The results of systematic studies were not consistent.

METHODS

A meta-analysis was performed to investigate the risk of acute pancreatitis associated with use of selective serotonin reuptake inhibitors.

RESULTS

There was no statistical association between the risk of acute pancreatitis and selective serotonin reuptake inhibitors use (odds ratio: 1.19, 95% confidence interval: 0.93-1.51).

CONCLUSIONS

Despite reaching no statistical significance, the possibility of the association between the risk of acute pancreatitis and selective serotonin reuptake inhibitors use cannot be totally excluded.

摘要

背景/目的：一些病例系列和病例报告显示了急性胰腺炎风险与选择性5-羟色胺再摄取抑制剂使用之间的关联。系统研究的结果并不一致。

方法

进行一项荟萃分析以调查与使用选择性5-羟色胺再摄取抑制剂相关的急性胰腺炎风险。

结果

急性胰腺炎风险与使用选择性5-羟色胺再摄取抑制剂之间无统计学关联（优势比：1.19，95%置信区间：0.93 - 1.51）。

结论

尽管未达到统计学显著性，但急性胰腺炎风险与使用选择性5-羟色胺再摄取抑制剂之间存在关联的可能性不能完全排除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3f5/7133076/4d3780f55623/10.1177_1559325820902352-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3f5/7133076/4d3780f55623/10.1177_1559325820902352-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3f5/7133076/4d3780f55623/10.1177_1559325820902352-fig1.jpg

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Postmarketing cases of eluxadoline-associated pancreatitis in patients with or without a gallbladder.上市后病例报告显示，埃卢昔单抗相关胰腺炎发生于有/无胆囊的患者中。
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