Roberts Stephen E, Morrison-Rees Sian, John Ann, Williams John G, Brown Tim H, Samuel David G
Swansea University, Medical School, Singleton Park, Swansea SA2 8PP, UK.
Swansea University, Medical School, Singleton Park, Swansea SA2 8PP, UK.
Pancreatology. 2017 Mar-Apr;17(2):155-165. doi: 10.1016/j.pan.2017.01.005. Epub 2017 Jan 19.
Acute pancreatitis is increasingly one of the most important acute gastrointestinal conditions throughout much of the world, although incidence and aetiology varies across countries and regions. This study investigated regional and national patterns in the incidence and aetiology of acute pancreatitis, demographic patterns in incidence and trends over time in incidence across Europe.
A structured review of acute pancreatitis incidence and aetiology from studies of hospitalised patient case series, cohort studies or other population based studies from 1989 to 2015 and a review of trends in incidence from 1970 to 2015 across all 51 European states.
The incidence of acute pancreatitis was reported from 17 countries across Europe and ranged from 4.6 to 100 per 100 000 population. Incidence was usually highest in eastern or northern Europe, although reported rates often varied according to case ascertainment criteria. Of 20 studies that reported on trends in incidence, all but three show percentage increases over time (overall median increase = 3.4% per annum; range = -0.4%-73%). The highest ratios of gallstone to alcohol aetiologies were identified in southern Europe (Greece, Turkey, Italy and Croatia) with lowest ratios mainly in eastern Europe (Latvia, Finland, Romania, Hungary, Russia and Lithuania).
The incidence of acute pancreatitis varies across Europe. Gallstone is the dominant aetiology in southern Europe and alcohol in eastern Europe with intermediate ratios in northern and western Europe. Acute pancreatitis continues to increase throughout most of Europe.
急性胰腺炎日益成为全球许多地区最重要的急性胃肠道疾病之一，尽管各国和各地区的发病率及病因有所不同。本研究调查了欧洲急性胰腺炎发病率和病因的区域及国家模式、发病率的人口统计学模式以及发病率随时间的变化趋势。
对1989年至2015年期间住院患者病例系列研究、队列研究或其他基于人群的研究中急性胰腺炎发病率和病因进行结构化综述，并对1970年至2015年期间所有51个欧洲国家的发病率趋势进行综述。
欧洲17个国家报告了急性胰腺炎的发病率，范围为每10万人中4.6至100例。发病率通常在东欧或北欧最高，不过报告的发病率常因病例确定标准而异。在20项报告发病率趋势的研究中，除三项外，其他所有研究均显示发病率随时间呈百分比上升（总体中位数年增长率 = 3.4%；范围 = -0.4% - 73%）。在南欧（希腊、土耳其、意大利和克罗地亚）胆结石病因与酒精病因的比例最高，而在东欧（拉脱维亚、芬兰、罗马尼亚、匈牙利、俄罗斯和立陶宛）比例最低。
欧洲急性胰腺炎的发病率各不相同。胆结石是南欧的主要病因，酒精是东欧的主要病因，北欧和西欧的比例居中。在欧洲大部分地区，急性胰腺炎的发病率持续上升。
