Ennaceur A, Delacour J
Laboratoire de Psychophysiologie, Université Paris VII, France.
Behav Brain Res. 1988 Nov 1;31(1):47-59. doi: 10.1016/0166-4328(88)90157-x.
In this paper we describe a new memory test in rats, based on the differential exploration of familiar and new objects. In a first trial (T1), rats are exposed to one or to two identical objects (samples) and in a second trial, to two dissimilar objects, a familiar (the sample) and a new one. For short intertrial intervals (approximately 1 min), most rats discriminate between the two objects in T2: they spend more time in exploring the new object than the familiar one. This test has several interesting characteristics: (1) it is similar to visual recognition tests widely used in subhuman primates, this allows interspecies comparisons; (2) it is entirely based on the spontaneous behavior of rats and can be considered as a 'pure' working-memory test completely free of reference memory component; (3) it does not involve primary reinforcement such as food or electric shocks, this makes it comparable to memory tests currently used in man.
在本文中，我们描述了一种基于对熟悉物体和新物体的差异探索的大鼠新记忆测试。在第一次试验（T1）中，大鼠接触一个或两个相同的物体（样本），在第二次试验中，接触两个不同的物体，一个是熟悉的（样本），另一个是新的。对于较短的试验间隔（约1分钟），大多数大鼠在T2中能区分这两个物体：它们花在探索新物体上的时间比熟悉物体的时间更多。该测试有几个有趣的特点：（1）它类似于在非人灵长类动物中广泛使用的视觉识别测试，这使得可以进行种间比较；（2）它完全基于大鼠的自发行为，可以被视为一种完全没有参考记忆成分的“纯粹”工作记忆测试；（3）它不涉及食物或电击等初级强化，这使得它可与目前用于人类的记忆测试相比较。
