Kamali Monireh, Manshouri Shirin, Bagheri Yasser, Rostami Masoumeh, Karkhaneh Mahmoudi Mahdi, Moradnejad Pardis, Seif Farhad
Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Immunology Research Center, Institute of Immunology and infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2020 Feb 11;34:4. doi: 10.34171/mjiri.34.4. eCollection 2020.
is an opportunistic, aerobic, nonfermentative, Gram-negative bacterium that can cause major nosocomial infections, especially in patients hospitalized in intensive care units (ICU). Recently, strains have been resistant to a variety of antibiotics. Thus, it was aimed to evaluate the prevalence of and their resistance to the antibiotics in the patients hospitalized in postcardiac surgery ICU. This retrospective cross sectional study was performed in Rajaei hospital between March 2014 and February 2016. strains were isolated from blood cultures, catheter cultures, sputum cultures, and wound smear cultures. Then, isolates were characterized using standard morphological, cultural, and biochemical properties according to CLSI 2016. The frequency of species were reported as percent. Among 27 167 patients were admitted to the ICU, 113 individuals, including 55 males and 58 females, were identified as A. baumannii-infected and the prevalence rate was 0.42%. The highest rates of antibiotic sensitivity were related to Meropenem 20 (17.7%) and Colistin 16 (14.1%). The shortest length of stay (LOS) for patients with in the ICU was 3 days, while the longest LOS was 98 days. The findings indicated that strains isolated from postcardiac surgery ICUs had a high prevalence and were sensitive to Meropenem and Colistin. However, new molecular-based techniques are needed to monitor nosocomial infections. Therefore, the treatment of the patients may be feasible by appropriate antibiotic therapy, and infection control policies will be improved by adopting precise disinfection strategies.
是一种机会性、需氧、非发酵、革兰氏阴性菌，可引起严重的医院感染，尤其是在重症监护病房（ICU）住院的患者中。最近，菌株对多种抗生素产生了耐药性。因此，旨在评估心脏手术后ICU住院患者中该菌的流行情况及其对抗生素的耐药性。这项回顾性横断面研究于2014年3月至2016年2月在拉贾伊医院进行。该菌从血培养、导管培养、痰培养和伤口涂片培养中分离出来。然后，根据CLSI 2016使用标准的形态学、培养和生化特性对分离株进行鉴定。该菌的种类频率以百分比报告。在27167名入住ICU的患者中，113人被确定为鲍曼不动杆菌感染，其中男性55人，女性58人，患病率为0.42%。抗生素敏感性最高的是美罗培南20例（17.7%）和黏菌素16例（14.1%）。该菌感染患者在ICU的最短住院时间为3天，最长住院时间为98天。研究结果表明，从心脏手术后ICU分离出的该菌菌株患病率较高，且对美罗培南和黏菌素敏感。然而，需要新的基于分子的技术来监测医院感染。因此，通过适当的抗生素治疗可能对患者进行可行的治疗，并且通过采用精确的消毒策略将改善感染控制政策。
