小麦诱发过敏反应患者小麦脱敏新方案的评估
Evaluation of a new protocol for wheat desensitization in patients with wheat-induced anaphylaxis.
作者信息
Rekabi Mahsa, Arshi Saba, Bemanian Mohammad Hassan, Rekabi Vahab, Rajabi Abolfazl, Fallahpour Morteza, Molatefi Rasool, Shokri Sima, Eslami Narges, Ahmadian Javad, Khoshmirsafa Majid, Seif Farhad, Mahdaviani Seyed Alireza, Akbarpour Nadieh, Nabavi Mohammad
机构信息
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis & Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Allergy & Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Immunotherapy. 2017 Jun;9(8):637-645. doi: 10.2217/imt-2017-0011.
AIM
New approaches such as oral immunotherapy (OIT) may be useful in IgE-mediated anaphylaxis to wheat.
PATIENTS & METHODS: 12 patients underwent OIT protocol that comprised of two phases: the first with semolina flour and the second with spaghetti. Total and specific wheat IgE were assayed by ELISA before and after OIT and 18 months later. Skin prick tests were also performed.
RESULTS
Patients successfully tolerated 50 g of wheat. The median baseline total IgE was decreased after up-dosing phase and decreased after follow-up (p < 0.01). The median baseline wheat-specific IgE was increased after up-dosing and decreased after follow-up (p < 0.001).
CONCLUSION
The efficiency and safety of our OIT protocol were shown on wheat allergic patients but further investigation is needed.
目的
口服免疫疗法（OIT）等新方法可能对小麦引发的IgE介导的过敏反应有用。
患者与方法
12名患者接受了OIT方案，该方案包括两个阶段：第一阶段使用粗粒小麦粉，第二阶段使用意大利面。在OIT前后及18个月后通过ELISA检测总小麦IgE和特异性小麦IgE。还进行了皮肤点刺试验。
结果
患者成功耐受了50克小麦。给药阶段后基线总IgE中位数降低，随访后也降低（p < 0.01）。给药后基线小麦特异性IgE中位数升高，随访后降低（p < 0.001）。
结论
我们的OIT方案在小麦过敏患者身上显示出了有效性和安全性，但仍需进一步研究。
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