非编码 RNA 与心血管系统概述。

An Overview of Non-coding RNAs and Cardiovascular System.

机构信息

Department of Biochemistry, Signal Transduction Laboratory, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.

出版信息

Adv Exp Med Biol. 2020;1229:3-45. doi: 10.1007/978-981-15-1671-9_1.

DOI:10.1007/978-981-15-1671-9_1

PMID:32285403

Abstract

Cardiovascular disease management and timely diagnosis remain a major dilemma. Delineating molecular mechanisms of cardiovascular diseases is opening horizon in the field of molecular medicines and in the development of early diagnostic markers. Non-coding RNAs are the highly functional and vibrant nucleic acids and are known to be involved in the regulation of endothelial cells, vascular and smooth muscles cells, cardiac metabolism, ischemia, inflammation and many processes in cardiovascular system. This chapter is comprehensively focusing on the overview of the non-coding RNAs including their discovery, generation, classification and functional regulation. In addition, overview regarding different non-coding RNAs as long non-coding, siRNAs and miRNAs involvement in the cardiovascular diseases is also addressed. Detailed functional analysis of this vast group of highly regulatory molecules will be promising for shaping future drug discoveries.

摘要

心血管疾病的管理和及时诊断仍然是一个主要的难题。阐明心血管疾病的分子机制为分子医学领域和早期诊断标志物的发展开辟了新的视野。非编码 RNA 是具有高度功能和活力的核酸，已知参与内皮细胞、血管和平滑肌细胞、心脏代谢、缺血、炎症和心血管系统的许多过程的调节。本章全面概述了非编码 RNA，包括它们的发现、产生、分类和功能调节。此外，还概述了不同的非编码 RNA，如长非编码 RNA、siRNA 和 miRNA 在内的心血管疾病中的作用。对这一庞大的高度调控分子群进行详细的功能分析，有望为未来的药物发现铺平道路。