调控非编码 RNA 相互作用与心血管疾病

Interactions Among Regulatory Non-coding RNAs Involved in Cardiovascular Diseases.

机构信息

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Cardiomics Unit, Centro de Cardiologia da Universidade de Lisboa (CCUL), Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

出版信息

Adv Exp Med Biol. 2020;1229:79-104. doi: 10.1007/978-981-15-1671-9_4.

DOI:10.1007/978-981-15-1671-9_4

PMID:32285406

Abstract

Non-coding RNAs (ncRNAs) are important regulatory players in human cells that have been shown to modulate different cellular processes and biological functions through controlling gene expression, being also involved in pathological conditions such as cardiovascular diseases. Among them, long non-coding RNAs (lncRNAs) and circular (circRNAs) could act as competing endogenous RNAs (ceRNAs) sequestering other ncRNAs. This entangled network of interactions has been reported to trigger the decay of the targeted ncRNAs having important roles in gene regulation. Growing evidences have been demonstrated that the regulatory mechanism underlying the crosstalk between different ncRNA species, namely lncRNAs, circRNAs and miRNAs has also an important role in the pathophysiological processes of cardiovascular diseases. In this chapter, the main regulatory relationship among lncRNAs, circRNAs and miRNAs were summarized and their role in the control and development of cardiovascular diseases was highlighted.

摘要

非编码 RNA（ncRNA）是人类细胞中重要的调节因子，已被证明通过控制基因表达来调节不同的细胞过程和生物学功能，同时也参与心血管疾病等病理状况。其中，长非编码 RNA（lncRNA）和环状 RNA（circRNA）可以作为竞争性内源 RNA（ceRNA）来隔离其他 ncRNA。据报道，这种相互交织的相互作用网络会引发靶向 ncRNA 的衰减，这些 ncRNA 在基因调控中具有重要作用。越来越多的证据表明，不同 ncRNA 物种（即 lncRNA、circRNA 和 miRNA）之间相互作用的调控机制也在心血管疾病的病理生理过程中起着重要作用。在本章中，总结了 lncRNA、circRNA 和 miRNA 之间的主要调控关系，并强调了它们在心血管疾病的控制和发展中的作用。