非编码 RNA 在糖尿病心肌病中的作用。
Role of Non-coding RNA in Diabetic Cardiomyopathy.
机构信息
Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
Adv Exp Med Biol. 2020;1229:181-195. doi: 10.1007/978-981-15-1671-9_10.
Diabetic cardiomyopathy (DCM) is the leading cause of morbidity and mortality in diabetic population worldwide, characteristic by cardiomyocyte hypertrophy, apoptosis and myocardial interstitial fibrosis and eventually developing into heart failure. Non-coding RNAs, such as microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and other RNAs without the protein encoding function were emerging as a popular regulator in various types of processes during human diseases. The evidences have shown that miRNAs are regulators in diabetic cardiomyopathy, such as insulin resistance, cardiomyocytes apoptosis, and inflammatory, especially their protective effect on heart function. Besides that, the functions of lncRNAs and circRNAs have been gradually confirmed in recent years, and their functions in DCM have become increasingly prominent. We highlighted the nonnegligible roles of non-coding RNAs in the pathological process of DCM and showed the future possibilities of these non-coding RNAs in DCM treatment. In this chapter, we summarized the present advance of the researches in this filed and raised the concern and the prospect in the future.
糖尿病心肌病（DCM）是全球糖尿病患者发病率和死亡率的主要原因，其特征为心肌细胞肥大、凋亡和心肌间质纤维化，最终发展为心力衰竭。非编码 RNA，如 microRNAs（miRNAs）、环状 RNA（circRNAs）、长非编码 RNA（lncRNAs）和其他不具有蛋白质编码功能的 RNA，作为一种新型调节剂，在人类疾病的各种过程中越来越受到关注。有证据表明，miRNAs 是糖尿病心肌病的调节因子，如胰岛素抵抗、心肌细胞凋亡和炎症，尤其是它们对心脏功能的保护作用。除此之外，近年来 lncRNAs 和 circRNAs 的功能逐渐得到证实，它们在 DCM 中的作用也越来越突出。我们强调了非编码 RNA 在 DCM 病理过程中的不可忽视的作用，并展示了这些非编码 RNA 在 DCM 治疗中的未来可能性。在本章中，我们总结了该领域研究的现状，并提出了未来的关注和展望。
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