Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan.
Sports Medical Center, Japan Institute of Sports Sciences, Tokyo, Japan.
Scand J Med Sci Sports. 2020 Aug;30(8):1379-1386. doi: 10.1111/sms.13679. Epub 2020 May 7.
The effects of transdermal estradiol treatment (HT) in amenorrheic athletes (AA) with low body weight (BW) and low bone mineral density (BMD) are unknown.
To investigate whether HT increases BMD in AA with low BW and to compare the results with levels in AA who have recovered spontaneous menstruation (SM).
Female athletes (n = 151) were recruited at the Japan Institute of Sports Sciences and the University of Tokyo. All participants were divided into four groups: an AA group (untreated group) (n = 36), a HT group (n = 55), a SM group (n = 21), and an eumenorrheic athletes (EA) group (n = 39). Height, body weight, blood tests, and dual-energy X-ray absorptiometry were measured at baseline and after 12 months. The HT group was treated daily for 12 months with transdermal estrogen therapy. In addition, participants received oral progestin for 7 days once every 3 months.
After 12 months, BMD in the AA group was significantly lower than at baseline; however, BMD in the other three groups was significantly higher than at baseline. The ratio of the change in BMD values before and after 12 months was -1.6 ± 3.2% for the AA group, 5.3 ± 8.7% for the HT group, 11.1 ± 8.9% for the SM group, and 2.3 ± 5.7% for the EA group. The rate of change in BMD values in the SM group was greater than that in the HT group.
HT increased BMD in AA with low BW, and the increase in those with SM was greater than that in those treated with HT.
经皮雌激素治疗（HT）对低体重（BW）和低骨密度（BMD）的闭经运动员（AA）的影响尚不清楚。
研究 HT 是否会增加 BW 低的 AA 的 BMD，并将结果与自发恢复月经（SM）的 AA 进行比较。
在日本体育科学研究所和东京大学招募了 151 名女运动员。所有参与者分为四组：AA 组（未治疗组）（n=36）、HT 组（n=55）、SM 组（n=21）和 EA 组（n=39）。在基线和 12 个月后测量身高、体重、血液检查和双能 X 线吸收法。HT 组接受为期 12 个月的经皮雌激素治疗，每天一次。此外，参与者每 3 个月口服孕激素 7 天。
12 个月后，AA 组的 BMD 明显低于基线，但其他三组的 BMD 明显高于基线。12 个月前后 BMD 值变化的比例，AA 组为-1.6±3.2%，HT 组为 5.3±8.7%，SM 组为 11.1±8.9%，EA 组为 2.3±5.7%。SM 组 BMD 值的变化率大于 HT 组。
HT 增加了 BW 低的 AA 的 BMD，而 SM 组的增加大于 HT 组。
