Jurist Research Department, Hackensack University Medical Center, Hackensack, New Jersey.
Viral Immunol. 2020 Apr;33(3):188-196. doi: 10.1089/vim.2019.0173.
Viruses and cytolytic lymphocytes operate in an environment filled with dying and dead cells, and cell fragments. For viruses, irreversible fusion with doomed cells is suicide. For cytotoxic T lymphocyte and natural killer cells, time and limited lytic resources spent on apoptotic targets is wasteful and may result in death of the host. We make the case that the target membrane cytoskeleton is the best source of information regarding the suitability of potential targets for engagement for both viruses and lytic effector cells, and we present experimental evidence for detection of apoptotic cells by HIV, without loss of infectivity.
病毒和细胞毒性淋巴细胞在充满垂死和死亡细胞以及细胞碎片的环境中运作。对于病毒来说，与注定死亡的细胞不可逆融合就是自杀。对于细胞毒性 T 淋巴细胞和自然杀伤细胞来说，将时间和有限的溶细胞资源浪费在凋亡靶标上是浪费的，并且可能导致宿主死亡。我们认为靶细胞膜细胞骨架是关于病毒和溶细胞效应细胞进行结合的潜在靶标的适宜性的最佳信息来源，并且我们提出了 HIV 通过不丧失感染力来检测凋亡细胞的实验证据。
