Assreuy-Filho J, Almeida A A, Guimarães J A
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 1988;21(3):453-5.
Partially purified kinin potentiating peptide (KPP) obtained from kininogen-depleted human plasma inhibited lung angiotensin converting enzyme in vitro and potentiated guinea-pig ileum contractions induced by bradykinin (BK), Lys-BK, Met-Lys-BK, Ile-Ser-BK, and Lys-Lys-BK. Contractions evoked by angiotensin II, histamine, acetylcholine, and barium chloride were not potentiated. KPP also potentiated kinin-induced contractions of rat uterus and of guinea-pig ileum pre-incubated with 1,10-phenanthroline. It is suggested that KPP potentiation is due, at least in part, to a direct effect on kinin receptor(s).
从去除激肽原的人血浆中获得的部分纯化的激肽增强肽（KPP）在体外可抑制肺血管紧张素转换酶，并增强缓激肽（BK）、赖氨酸-缓激肽（Lys-BK）、甲硫氨酸-赖氨酸-缓激肽（Met-Lys-BK）、异亮氨酸-丝氨酸-缓激肽（Ile-Ser-BK）和赖氨酸-赖氨酸-缓激肽（Lys-Lys-BK）诱导的豚鼠回肠收缩。血管紧张素II、组胺、乙酰胆碱和氯化钡引起的收缩未被增强。KPP还增强了激肽诱导的大鼠子宫收缩以及与1,10-菲咯啉预孵育的豚鼠回肠收缩。提示KPP的增强作用至少部分是由于对激肽受体的直接作用。
