Menezes A M, Rao V S
Departamento de Fisiologia e Farmacologia, Universidade Federal do Piauí, Terezina, Brasil.
Braz J Med Biol Res. 1988;21(3):531-3.
In order to assess the use of Astronium urundeuva in folk medicine for treatment of diarrheal conditions, the alcoholic extract of its bark was tested on gastrointestinal transit in mice. The extract at oral doses of 100 and 200 mg/kg significantly inhibited physostigmine-induced gastrointestinal propulsion. Considering these data together with an in-vitro anti-acetylcholine effect reported earlier from this laboratory, we suggest that anti-cholinergic effects of the plant may account in part for its anti-diarrheal activity.
为了评估巴西苏木在民间医学中治疗腹泻病症的应用，对其树皮的乙醇提取物进行了小鼠胃肠道转运试验。口服剂量为100和200 mg/kg的提取物显著抑制了毒扁豆碱诱导的胃肠道蠕动。结合本实验室先前报道的体外抗乙酰胆碱作用来看这些数据，我们认为该植物的抗胆碱能作用可能部分解释了其抗腹泻活性。
