阿扑吗啡不能模拟快速眼动睡眠剥夺对皮层扩散性抑制的影响。
Apomorphine does not mimic the effects of REM-sleep deprivation on cortical spreading depression.
作者信息
Amorim L F, Guedes R C, Medeiros M C, da Silva A T, Cabral-Filho J E
机构信息
Departamento de Nutrícão, Universidade Federal de Pernambuco, Recife, Brasil.
出版信息
Braz J Med Biol Res. 1988;21(3):611-4.
The propagation of cortical spreading depression (SD) and the incidence of "spontaneous" SD were enhanced in rats after rapid-eye-movement sleep deprivation (REMD) as compared to control animals. Pseudo-deprived rats were similar to controls, suggesting that the facilitatory effect on SD is due to REMD rather than to the stress accompanying deprivation. In control rats, apomorphine (0.5 to 8 mg/kg) failed to reproduce the effects of REMD and also failed to enhance the REMD effects in deprived rats, suggesting that the dopaminergic system does not play an important role in propagation of cortical SD.
与对照动物相比，快速眼动睡眠剥夺（REMD）后的大鼠皮质扩散性抑制（SD）的传播以及“自发性”SD的发生率均有所增加。假剥夺大鼠与对照相似，这表明对SD的促进作用是由于REMD而非剥夺伴随的应激所致。在对照大鼠中，阿扑吗啡（0.5至8毫克/千克）未能重现REMD的效应，也未能增强剥夺大鼠的REMD效应，这表明多巴胺能系统在皮质SD的传播中不发挥重要作用。
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