地塞米松可逆转快速眼动睡眠剥夺对阿扑吗啡诱发啃咬行为的影响。

REM sleep deprivation effect on apomorphine-induced gnawing is reversed by dexamethasone.

作者信息

Nez L, Kubota J, Warren M, Henderson R, Phillips M, Schreiber H L

出版信息

Sleep. 1985;8(3):283-7. doi: 10.1093/sleep/8.3.283.

DOI:10.1093/sleep/8.3.283

Abstract

Glucocorticoid feedback was manipulated in rats deprived of REM for six days or left undisturbed in their home cages. One half of each group received concurrent dexamethasone (400 micrograms/kg), while the other half received corn oil. On test day, rats were observed for 5 min, injected with apomorphine (0.8 mg/kg, i.p.), and again observed. Dexamethasone revealed REM-deprivation-enhanced stereotypical gnawing, but had no effect on REM-deprivation-reduced rearing, suggesting the involvement of catecholamine depletion by non-specific stress-related factors in the former REM deprivation effect.

摘要

对剥夺快速眼动睡眠（REM）六天的大鼠或在其饲养笼中未受干扰的大鼠进行糖皮质激素反馈调节。每组的一半大鼠同时接受地塞米松（400微克/千克），而另一半接受玉米油。在测试日，观察大鼠5分钟，腹腔注射阿扑吗啡（0.8毫克/千克），然后再次观察。地塞米松显示出REM剥夺增强的刻板啃咬行为，但对REM剥夺减少的竖毛行为没有影响，这表明在前一种REM剥夺效应中，非特异性应激相关因素导致的儿茶酚胺耗竭起了作用。