快速眼动睡眠剥夺后大鼠对阿扑吗啡高反应性的持续存在及饲养条件的影响。

The persistence of hyperresponsiveness to apomorphine in rats following REM sleep deprivation and the influence of housing conditions.

作者信息

Dallmeier Zelger K, Carlini E A

出版信息

Eur J Pharmacol. 1982 May 7;80(1):99-104. doi: 10.1016/0014-2999(82)90182-0.

PMID:7201405

Abstract

The hyperresponsiveness to apomorphine disappears after REM sleep deprivation of rats; the time course of the disappearance was investigated. When REM sleep-deprived (REMd) rats were caged individually during the recovery period the increase in ambulation and in stereotyped behaviour elicited by apomorphine subsided within 8-24 h; on the other hand, the exaggerated aggressiveness persisted up to 64 days. However, when the deprived rats were allowed to recovery in groups of 3 per cage the increase in aggressiveness subsided after 4 days. Since individual housing of non-deprived rats for 4--11 days increased the apomorphine-aggressiveness steadily, 'isolation' probably summed with REM deprivation in facilitating the effects of apomorphine on aggressive behaviour. The results also suggest that the dopaminergic systems implicated in aggressive behaviour are sensitized by REM deprivation for a longer period than those subjacent to ambulation and stereotype.

摘要

大鼠快速眼动睡眠剥夺后对阿扑吗啡的高反应性消失；对其消失的时间进程进行了研究。在恢复期将快速眼动睡眠剥夺（REMd）大鼠单独关笼时，阿扑吗啡引起的活动增加和刻板行为在8 - 24小时内消退；另一方面，过度攻击性持续长达64天。然而，当将剥夺睡眠的大鼠每笼3只一起饲养让其恢复时，攻击性增加在4天后消退。由于将未剥夺睡眠的大鼠单独饲养4 - 11天会使阿扑吗啡诱导的攻击性稳步增加，“隔离”可能与快速眼动睡眠剥夺共同作用，促进了阿扑吗啡对攻击行为的影响。结果还表明，与攻击行为相关的多巴胺能系统比与活动和刻板行为相关的多巴胺能系统对快速眼动睡眠剥夺更为敏感，且这种敏感性持续时间更长。