Department of Ophthalmology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Department of Ophthalmology & Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sci Rep. 2020 Apr 14;10(1):6362. doi: 10.1038/s41598-020-63486-7.
Glaucomatous visual field (VF) damage usually involves in the Bjerrum area, which refers to outside the central 10° region. However, some reports suggest that structural damage to the macula occurs even in the early stages of glaucoma. We investigated the characteristics of normal tension glaucoma (NTG) patients with temporal retinal nerve fibre layer (RNFL) defects. Ninety eyes from 90 subjects including 30 normal eyes, 30 eyes of 30 patients with normal-tension glaucoma with temporal RNFL defects, and 30 eyes of 30 patients with normal-tension glaucoma with inferotemporal or superotemporal RNFL defects were enrolled. The best-corrected visual acuity (BCVA) decreased significantly in glaucomatous eyes with temporal RNFL defects as compared with in controls and glaucomatous eyes with inferotemporal or superotemporal RNFL defects. VF tests showed more frequent central or cecocentral VF defects involving the central 10° region in glaucomatous eyes with temporal RNFL defects. VF defects were more frequently detected on short-wavelength automated perimetry (SWAP). Eyes with temporal RNFL defects had generally reduced ganglion cell-inner plexiform layer (GCIPL) thickness. In addition, the BCVA, GCIPL thicknesses, and SWAP findings were significantly different in glaucoma patients with temporal RNFL defects according to their colour vision deficiency, not RNFL thickness or standard automated perimetry (SAP) results.
青光眼视野（VF）损害通常涉及 Bjerrum 区，即中央 10°区域以外的部位。然而，一些报告表明，即使在青光眼的早期阶段，黄斑区也会发生结构损害。我们研究了具有颞侧视网膜神经纤维层（RNFL）缺损的正常眼压性青光眼（NTG）患者的特征。纳入了 90 只眼，共 90 例受试者，包括 30 只正常眼、30 只具有颞侧 RNFL 缺损的正常眼压性青光眼眼和 30 只具有颞下或颞上 RNFL 缺损的正常眼压性青光眼眼。与对照组和具有颞下或颞上 RNFL 缺损的青光眼眼相比，具有颞侧 RNFL 缺损的青光眼眼的最佳矫正视力（BCVA）明显下降。VF 测试显示，具有颞侧 RNFL 缺损的青光眼眼更频繁地出现涉及中央 10°区域的中央或中央旁 VF 缺损。短波长自动视野计（SWAP）更频繁地检测到 VF 缺损。具有颞侧 RNFL 缺损的眼通常表现为神经节细胞内丛状层（GCIPL）厚度降低。此外，根据颜色视觉缺陷，而不是 RNFL 厚度或标准自动视野计（SAP）结果，具有颞侧 RNFL 缺损的青光眼患者的 BCVA、GCIPL 厚度和 SWAP 结果存在显著差异。
